Burinex® Leo: A Short-Acting Diuretic

Burinex® Leo is a potent diuretic medication known for its rapid onset and short duration of action. This blog post will provide essential information about Burinex® Leo, its properties, indications, and dosage.


Burinex® Leo contains two tablet strengths: 1 mg and 5 mg, with the active ingredient being Bumetanide.

  • High-Ceiling Diuretic: Burinex® Leo is a high-ceiling diuretic, known for its powerful effects on promoting diuresis.
  • Rapid Onset: Upon oral administration, Burinex® Leo is quickly absorbed by the body, and diuresis typically begins within 30 minutes.
  • Short Duration: The diuretic effect of Burinex® Leo has a short duration, with a peak effect occurring between 1 and 2 hours.
  • Individualized Timing: Its short action allows patients to time diuresis according to their needs, minimizing disruptions to their daily routine.

Burinex® Leo’s diuretic effect is dose-related, meaning that patients who do not respond to a low initial dose may find relief with higher doses. It primarily affects the ascending limb of the loop of Henle but may also have additional actions in the proximal tubule. Clinical investigations have consistently demonstrated that Burinex® Leo is both effective and well-tolerated.


Burinex® Leo is indicated for various conditions where diuretic therapy is necessary. These include:

  • Edema: Associated with congestive heart failure, cirrhosis of the liver, renal diseases (including nephrotic syndrome), and acute pulmonary edema.
  • Fluid Retention: In cases of drug-induced fluid retention.
  • Forced Diuresis: For drug poisoning cases that respond to forced diuresis.
  • Hypertension: In some cases, Burinex® Leo may be prescribed for hypertension.


  • Oral Administration: The usual starting dose is 1 tablet daily.
  • Adjustable Dosing: In refractory cases, the dose can be gradually increased until a satisfactory response is achieved. Rarely, doses of up to 4 mg daily may be required.
  • 5 mg Tablets: The 5 mg tablet is reserved for use in resistant edema due to renal insufficiency or when higher doses are needed. Consider twice-daily dosing in high-dose therapy.
  • Children: For children, the dose is calculated based on body weight, typically ranging from 0.03 to 0.06 mg/kg daily.
  • Elderly: In elderly patients, dosage adjustments should be made according to their response, with some requiring only 0.5 mg daily.

In conclusion, Burinex® Leo is a valuable diuretic medication with a rapid onset, short duration of action, and flexible dosing options. It is commonly prescribed to manage edema associated with various medical conditions, offering patients relief and improved quality of life. Always follow your healthcare provider’s recommendations when taking Burinex® Leo, and do not hesitate to ask questions or seek clarification on its use.