BIOFLOR 250mg Capsules: Your Guide to Usage and Safety

Are you prescribed BIOFLOR 250mg capsules containing Saccharomyces boulardii CNCM I-745 and wondering how to use them safely and effectively? This article provides you with essential information, without any medical jargon, so you can confidently take your medication.

What’s Inside this Article

  1. Understanding BIOFLOR 250mg Capsules
  2. What to Know Before Taking BIOFLOR 250mg Capsules
  3. Proper Usage of BIOFLOR 250mg Capsules
  4. Potential Side Effects
  5. Storing BIOFLOR 250mg Capsules
  6. Additional Information

1. Understanding BIOFLOR 250mg Capsules

BIOFLOR 250mg capsules belong to the pharmacotherapeutic group of anti-diarrhea and are used to restore the gut flora. They have various therapeutic indications, including:

  • Treatment of Acute Infectious Diarrhea: Suitable for both adults and children.
  • Prevention and Treatment of Antibiotic-Associated Colitis and Diarrhea: Important when you’re on antibiotics.
  • Addition to Vancomycin/Metronidazole Treatment: Helps prevent the recurrence of Clostridium difficile diseases.
  • Prevention of Tube-Feeding Associated Diarrhea: Useful in clinical settings.
  • Irritable Bowel Syndrome: Offers a treatment option for this condition.

2. What to Know Before Taking BIOFLOR 250mg Capsules

Do NOT take BIOFLOR 250mg capsules if:

  • You are allergic to Saccharomyces boulardii CNCM I-745 or any of the other ingredients.
  • You have a central venous catheter.
  • You are immunocompromised or hospitalized due to a serious illness or a weakened immune system.


  • If you’re around patients with a central venous catheter, avoid opening capsules to prevent contamination.
  • It’s also advisable not to open capsules around critically ill or immunocompromised patients due to the risk of airborne contamination.
  • Follow dietary guidelines, including rehydration with salted or sweetened drinks, especially to compensate for fluid loss from diarrhea.

Consult your doctor if:

  • You see no improvement after 2 days of treatment.
  • You experience fever, vomiting, blood, or mucus in your stools.
  • You have intense thirst and dryness of the tongue, which could indicate dehydration.

3. Proper Usage of BIOFLOR 250mg Capsules

To use BIOFLOR 250mg capsules:

  • Adults and children above 6 years: Take 1 or 2 capsules once or twice daily.
  • Swallow the capsules with a glass of water.
  • Avoid using capsules in children under 6 years; opt for the powder for oral suspension in sachets.

4. Potential Side Effects

Like all medicines, BIOFLOR 250mg capsules may have side effects. These can include:

  • Rare: Flatulence (in up to 1 in 1,000 people).
  • Very Rare: Allergic reactions such as pruritus, urticaria, skin rash, anaphylactic reactions, and in rare cases, fungemia (yeast in the blood).
  • Frequency Unknown: Constipation.

5. Storing BIOFLOR 250mg Capsules

Remember these storage instructions:

  • Keep out of children’s reach.
  • Do not use after the expiry date mentioned on the packaging.
  • Store below 25°C and away from humidity.
  • Dispose of any unused medication according to your pharmacist’s guidance to protect the environment.

6. Additional Information

What BIOFLOR 250mg Capsules Contain:

  • Active substance: Saccharomyces boulardii CNCM I-745 (250.00mg).
  • Other ingredients: Lactose, magnesium stearate. Capsule shell: gelatine, titanium dioxide (E171).


Opaque white capsules containing a light brown powder with a characteristic odor. Box of 10 capsules in a glass bottle.

Contact Information:

  • Marketing Authorization Holder: BIOCODEX, 7 avenue Gallieni, Gentilly – France
  • Manufacturer: BIOCODEX, 1 avenue Blaise Pascal, Beauvais – France

This information is based on the leaflet revised in January 2019. Always consult your doctor or pharmacist for personalized advice. Your health is important, and understanding your medication is a crucial step towards well-being.