Barcimiant 2 mg or 4 mg Oral Tablets: INDICATIONS, SIDE EFFECTS, DOSAGE, INTERACTIONS…

Barcimiant is a medicine that is taken by mouth. It is used to treat moderate to severe rheumatoid arthritis. Barcimiant helps reduce pain and swelling, and it also helps slow the progression of bone and joint damage. Barcimiant belongs to a class of drugs that work by decreasing the activity of the immune system called disease-modifying antirheumatic drugs (DMARDs).

Barcimiant is used alone or with other medications to treat rheumatoid arthritis, a condition in which the body’s autoimmune system attacks the body’s own joints, causing pain, swelling, and loss of normal joint function. Barcimiant is indicated for the treatment of adults (over 18 years of age) with rheumatoid arthritis who have not responded well to one or more other conventional medicines (eg TNF inhibitors or methotrexate).

Barcimiant may also be used in combination with antivirals such as remdesivir to treat coronavirus disease (COVID-19) in adults who are isolated in hospital, who need supplemental oxygen or mechanical ventilation (a ventilator machine that helps the patient breathe).

In June 2022, the US Food and Drug Administration approved Baricitinib (the active ingredient in Barcimiant) to treat adults with severe alopecia areata.

Your dose will depend on the condition being teated, other medications you are taking, and the patient’s general health. The most common side effects of Barcimiant tablets include sore throat and nose, nausea, and an increased risk of viral infections.

Barcimiant can cause a number of other side effects, such as high cholesterol, low blood cell counts, and headache. More serious side effects – such as infection and blood clots – are also possible.

Treatment with Barcimiant may also cause you to develop cold sores, feeling sick, or have flu or cold symptoms such as stuffy nose, sneezing, and sore throat. There are other less common side effects, but some are serious, including the formation of blood clots.

You will need to have blood tests before taking this medicine (such as checking your blood cell count and liver function). Your doctor will also make sure that you are free of any infection before prescribing Barcimiant. You should tell your doctor before starting treatment if you have an infection (current or ever) with tuberculosis, shingles, kidney or liver disease, hepatitis B or C, or blood clots in your legs or lungs.

Barcimiant can make you more likely to get an infection or worsen an existing infection, so avoid contact with people who have illnesses you may have (eg, chickenpox, measles, or the flu). This medicine is not suitable for children under 18 years of age, and you should not use it if you are pregnant or breastfeeding unless your doctor feels that the benefit outweighs the risks.

What do you need to know about Barcimiant?

Barcimiant can cause an infection or a worsening of the infection

Barcimiant may worsen an existing infection, increase the risk that you will develop a new infection, or increase the risk of viral reactivation. Therefore, the patient should be instructed to inform the doctor if he develops symptoms of infection, such as:

  • Fever, sores, feeling more tired than usual, or dental problems
  • Cough that does not go away, night sweats and weight loss. These may be symptoms of tuberculosis (a contagious lung disease).
  • Skin rash accompanied by pain and blisters. This symptom may be a sign of shingles infection.

Barcimiant can increase the chances of blood clots forming in the veins

Tell the doctor, before and during treatment with Barcimiant, if you have ever had blood clots in the veins of the feet (deep vein thrombosis) or in the lungs (pulmonary embolism). Tell your doctor if you have a swollen and painful leg, redness or a feeling of heat in the leg, chest pain or shortness of breath, as these could be signs of blood clotting in the veins.

Barcimiant is forbidden during pregnancy

Do not take Barcimiant if you are pregnant or suspect that you may be pregnant. Therefore, use effective contraception during treatment with Barcimiant (and for one week thereafter, if you stop treatment). Tell your doctor immediately if you become pregnant (or if you want to become pregnant).

Barcimiant increases levels of fats in the blood

The use of Barcimiant may cause an increase in the level of fats in the blood. Your doctor will regularly check the levels of fats in your blood, such as cholesterol, during your treatment with Barcimiant.

What is Barcimiant? How to use it?

Barcimiant, a drug containing the active ingredient baristinib; It belongs to a class of medicines called disease-modifying antirheumatic drugs. Barcimiant is a drug approved for the treatment of moderate to severe rheumatoid arthritis in adults. This drug can reduce joint damage and disability caused by rheumatoid arthritis. Barcimiant is often prescribed alone or in combination with other medications to treat rheumatoid arthritis. This drug suppresses the immune system to reduce the inflammation that causes pain and swelling in rheumatoid arthritis.

Usual Continuing Dose: A 4 mg dose of Barcimiant is usually given once daily. Sometimes, only 2 mg is given to some patients, especially if they experience side effects with the 4 mg dose. Also, a dose of 2 mg is recommended for patients over 75 years of age, and for people with kidney problems.

Barcimiant should be taken with food. It may take several weeks after you start using Barcimiant to notice an improvement in joint pain or swelling. The full benefits of the medication may not be noticed until 6 to 12 weeks after starting the medication. It is important to have regular blood tests, including liver function tests, while taking this medicine.

You should not take Barcimiant if you have current or previous liver problems, such as hepatitis or cirrhosis. Because alcohol may increase the risk of liver damage, alcohol/wine should be avoided during treatment with Barcimiant.

Barcimiant systemic treatment for alopecia areata

In June 2022, the US Food and Drug Administration approved baristinib (the active ingredient in Barcimiant) for the treatment of adults with severe alopecia areata.

Alopecia areata is an autoimmune disease that causes the body’s immune system to attack hair follicles, leading to inflammation and gradual hair loss. It tends to start initially as small patches of hair loss from the scalp, but can progress to total hair loss on the scalp and other parts of the body.

Barcimiant is usually given together with other topical (applied to the skin) treatments for alopecia areata . Barcimiant is the first fully approved oral treatment option for the treatment of alopecia areata. Barcimiant works by blocking the action of certain enzymes (Janos kinase), which play a role in sending immune signals and cause inflammation in our bodies.

It is not fully understood how the immune system causes alopecia areata. But there are many different immune signals that affect the hair growth cycle, and potentially lead to hair loss. Barcimiant blocks the immune signals that cause hair loss, allowing hair to grow again.

For most people, the recommended dose of Barcimiant is 2 mg (one tablet) orally once a day. Some people may be treated with up to 4 mg once a day. Your health care provider will determine the right dose for you based on your symptoms and how you respond to the medication.

What procedures should be followed during the treatment period with Barcimiant pills

Complete blood count, liver and kidney function, as well as blood lipid levels should be performed periodically during the treatment period with Barcimiant tablets.

Also, all patients should be advised during the course of treatment with Barcimiant to avoid contact with individuals with microbial infections due to the weakening of the immune system to resist microbial infections while taking Barcimiant.

If a patient develops a severe infection during the course of treatment with Barcimiant tablets, the doctor may have to stop Barcimiant temporarily until the patient recovers from this infection. It is also important to advise the patient not to receive any vaccinations or immunizations during the period of treatment with Barcimiant pills.

Side Effects

The weakness of the body’s ability to resist diseases is one of the most famous negative effects of Barcimiant pills, so the patient increases the possibility of catching an infection with bacterial or viral infectious diseases, and the possibility of activation of any latent or inactive infection such as hepatitis B or C or latent herpes infection increases.

Among the side effects that may be associated with treatment with Barcimiant are: a general feeling of weakness and headache; gastrointestinal symptoms such as stomach pain, feeling sick, vomiting, diarrhoea; tingling sensation in the body; ringing in the ears; bone and muscle pain; high levels of blood fats; Swelling in the feet.

اولوميانت ٤ مجم أقراص فموية
Barcimiant is a generic of Olumiant

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