Bacticlor: A Comprehensive Guide to Understanding and Safely Using Your Medication

Welcome to the comprehensive guide on Bacticlor, a medication designed to combat various infections effectively. As a seasoned medical professional, I’m here to provide you with insights into the composition, indications, suggested doses, and practical tips for using Bacticlor. Let’s delve into the world of pharmaceutical knowledge and empower you with the information you need.

Component Benefits

Bacticlor contains cefaclor USP, a semi-synthetic broad-spectrum cephalosporin antibiotic. This powerful antibiotic exhibits significant activity against both gram-positive and gram-negative bacteria. Cefaclor achieves its bactericidal action by inhibiting bacterial cell-wall synthesis. Notably, it remains stable in the presence of certain bacterial beta-lactamases, making it effective against organisms producing these enzymes.

Indications for Use

Bacticlor is a versatile medication indicated for various infections caused by susceptible strains of bacteria. Here’s a breakdown of the conditions it treats:

  1. Respiratory Tract Infections:
  • Upper respiratory tract infections, including otitis media, pharyngitis, tonsillitis, and sinusitis.
  • Lower respiratory tract infections, such as Acute Bacterial Exacerbations of Chronic Bronchitis (ABECB) and Secondary Bacterial Infection of Acute Bronchitis (SBIAB).
  • Pneumonia.
  1. Urinary Tract Infections:
  • Cystitis, pyelonephritis, and asymptomatic bacteriuria.
  1. Skin and Skin Structure Infections:
  • Infections of the skin and underlying structures.

Suggested Doses

Understanding the appropriate dosage is crucial for the effective use of Bacticlor. Here are the recommended doses for different formulations:

  1. Bacticlor Capsules 500 mg:
  • For children over 12 years and adults: 500 mg every 8 hours, doubled for severe infections, with a maximum of 4 g daily.
  1. Bacticlor Oral Suspension (125 mg and 250 mg/5mL after constitution):
  • Usual recommended dosage is 20 mg/kg in divided doses every 8 hours, with doses doubled for severe infections.
  • Specific dosage for different age groups:
    • 1 month-1 year: 62.5 mg
    • 1-5 years: 125 mg
    • Over 5 years: 250 mg

Ensure that Bacticlor is administered for at least 10 days in the treatment of beta-hemolytic streptococcal infections.

Advice and Instructions

Renal Impairment

Cefaclor should be used cautiously in individuals with significantly impaired renal function. Dosage adjustments based on creatinine clearance are as follows:

  • Creatinine clearance > 40 mL/min/1.73m²: No modification
  • Creatinine clearance 40 to 10 mL/min/1.73m²: 50% of the usual 24-hour dose
  • Creatinine clearance < 10 mL/min/1.73m²: 25% of the usual 24-hour dose

Hepatic Impairment

No dosage adjustment is necessary for patients with hepatic impairment, as cefaclor is not metabolized in the liver.

Method of Preparation of Oral Suspension

For the oral suspension, follow these steps:

  • Shake the bottle to loosen the powder.
  • Add an appropriate amount of water (40 mL) in two portions.
  • Invert the bottle and shake it well after each addition.
  • When constituted, the suspension is red with a sweet taste and strawberry-like flavor.
  • Keep the bottle tightly closed, store it in the refrigerator, and use it within 14 days after preparation.

Adverse Reactions

While most adverse reactions to Bacticlor are mild and transient, it’s essential to be aware of potential side effects. Common adverse reactions include nausea, vomiting, diarrhea, abdominal pain, and hypersensitivity reactions like rash and urticaria. Other reported reactions, though rare, include slight elevations of liver enzymes, prolonged prothrombin time, genital pruritis, and vaginal moniliasis. Dizziness, somnolence, and insomnia have been reported rarely.


In the unlikely event of overdosage, the recommended treatment includes activated charcoal to reduce drug absorption, airway protection, and monitoring of vital signs. Although cefaclor is considered dialysable, specific interventions like forced diuresis or hemodialysis haven’t proven beneficial in cefaclor overdosage.


Store Bacticlor below 25 °C, protected from moisture. Keep all medicines out of reach of children.


Armed with this comprehensive guide, you are now better equipped to navigate the usage of Bacticlor. Always adhere to the prescribed dosage, follow the provided instructions, and consult your healthcare professional if you experience any concerning side effects. Remember, this guide serves as an informational tool, and personalized medical advice should be sought for your unique circumstances. Bacticlor, when used judiciously, stands as a valuable ally in the fight against various bacterial infections.