AZOMYCIN: A Broad Spectrum Antibiotic

AZOMYCIN is a powerful antibiotic available in both capsule and powder for oral suspension forms, designed to combat a wide range of infections caused by susceptible microorganisms. In this blog post, we’ll delve into the composition, properties, pharmacokinetics, antimicrobial spectrum, and indications of this potent medication.


  • Capsules: Each capsule contains Azithromycin dihydrate equivalent to 250 mg azithromycin base.
  • Oral Suspension: Each 5 ml of oral suspension contains Azithromycin dihydrate equivalent to 200 mg azithromycin base.


AZOMYCIN contains Azithromycin, a member of a new subclass of macrolide antibiotics known for their broad spectrum of activity, sustained tissue antibiotic levels, and expanded therapeutic range. It exhibits remarkable effectiveness against various microorganisms, making it a preferred choice for many medical professionals.

Key Attributes:

  • Gram-Positive Bacteria: AZOMYCIN is particularly potent against Gram-positive bacteria, surpassing other macrolides in its effectiveness against Gram-negative bacteria, including Haemophilus influenzae.
  • Atypical Intracellular Organisms: This antibiotic also targets atypical intracellular organisms such as Mycoplasma pneumoniae and Chlamydia trachomatis.
  • Protein Synthesis Inhibition: AZOMYCIN inhibits protein synthesis by dissociating RNA from ribosomes, ultimately suppressing the growth of susceptible microorganisms.
  • Clinical Advantages: AZOMYCIN therapy offers several advantages, including high cure rates, once-daily dosing, short treatment courses, and excellent patient compliance. Notably, it is well-tolerated even by patients allergic to penicillin, with a rare incidence of gastrointestinal side effects commonly encountered with other macrolides.


Understanding the pharmacokinetics of AZOMYCIN is crucial for effective treatment:

  • Absorption: Azithromycin is rapidly absorbed from the gastrointestinal tract (GIT) after oral administration. To optimize absorption, it is advisable to take the medication on an empty stomach, as food can affect absorption.
  • Distribution: The drug is widely distributed throughout the body’s tissues and fluids. Interestingly, more of the drug is found in tissues than in plasma.
  • Metabolism: Only a small fraction of the oral dose undergoes metabolism in the liver.
  • Excretion: Azithromycin is primarily excreted in bile as unchanged drug and metabolites, with approximately 6% excreted in urine.
  • Half-Life: AZOMYCIN boasts an extended half-life ranging from 40-60 hours. There is still uncertainty regarding its presence in breast milk or crossing the placenta.

Antimicrobial Spectrum

AZOMYCIN exhibits a broad antimicrobial spectrum, making it effective against various bacteria and microorganisms. Here’s a glimpse of its coverage:

Gram-Positive Aerobic Bacteria:

  • Staphylococcus aureus
  • Staph. epidermidis
  • Streptococcus pyogenes
  • Strep. viridans
  • Strep. agalactiae
  • Strep. pneumoniae
  • Other Streptococcus spp.

Gram-Negative Aerobic Bacteria:

  • Haemophilus influenzae
  • H. ducreyi
  • Moraxella catarrhalis
  • Neisseria gonorrhoeae
  • Legionella pneumophila
  • Bordetella pertussis
  • Shigella spp.
  • Escherichia coli
  • Salmonella
  • Aeromonas spp.

Anaerobic Bacteria:

  • Bacteroides fragilis and other Bacteroides spp.
  • Clostridium perfringens
  • Peptostreptococcus spp.

Other Microorganisms:

  • Chlamydia trachomatis
  • Chlamydia pneumoniae
  • Treponema pallidum
  • Borrelia burgdorferi
  • Toxoplasma gondii
  • Mycoplasma pneumoniae
  • Mycoplasma hominis
  • Ureaplasma urealyticum
  • Mycobacterium avium


AZOMYCIN is indicated for the treatment of infections caused by susceptible microorganisms, including:

  • Upper Respiratory Tract Infections: Otitis media, sinusitis, pharyngitis, and tonsillitis.
  • Lower Respiratory Tract Infections: Acute exacerbation of chronic bronchitis, community-acquired pneumonia, and exacerbations of chronic obstructive pulmonary disease (COPD).

In conclusion, AZOMYCIN is a versatile and effective antibiotic with a wide range of applications in the treatment of bacterial and atypical infections. Its favorable pharmacokinetics, broad antimicrobial spectrum, and patient-friendly dosing make it a valuable tool in the fight against infections caused by susceptible microorganisms. Always consult your healthcare provider for guidance on proper usage and dosage of this medication.

Produced by Pharco Pharmaceuticals, Alexandria

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