Apidone® syrup – Antihistaminic Anti-inflammatory


Each 5 ml contains:

  • Dexamethasone: 0.5 mg.
  • Chlorpheniramine maleate: 2 mg.


Apidone® is a combination of synthetic glucocorticoid ( Dexamethasone) and antihistaminic (Chlorpheniramine maleate).

Dexamethasone properties

  1. Has a potent anti-inflammatory effect (7 times the potency of prednisolone).
  2. Lacks the sodium-retaining properties of hydrocortisone due to its insignificant mineralocorticoid activity.
  3. Inhibits the inflammatory response whatever the cause is; chemical, traumatic, Infectious or immunological.
  4. Reduces not only early manifestation of the inflammatory process (edema, fibrin deposition, capillary dilatation, migration of leukocytes into the inflamed area and phagocytic activity), but also the later manifestations (proliferation of capillaries).
  5. Suppresses allergic responses.

Chlorpheniramine maleate properties

  1. Is one of the most potent antihistamines with a rapid onset of action.
  2. Antagonizes the physiological actions of histamine by acting as an H1-receptor blocking agent.
  3. Controls the allergic reaction associated with rhinitis, bronchial asthma, dermatological disorders and other allergic conditions.


Apidone®is mainly indicated in inflammatory conditions, some severe allergic diseases and glucocorticoid deficiency cases, such as:

  • Bronchial asthma
  • Urticaria and Angioedema
  • Allergic Rhinitis
  • Atopic and contact dermatitis
  • Hypersensitivity reactions to drugs, chemicals, and insect bites
  • Steven Johnson syndrome and other allergic disorders
  • Some endocrine diseases, e.g., congenital adrenal hyperplasia
  • Some rheumatic diseases, e.g., rheumatoid arthritis


As with other corticosteroids, it is contraindicated in:

  • Systemic fungal infection.
  • Administration of live virus vaccines.
  • Tuberculosis
  • Gastric and duodenal ulcers.
  • Pregnancy and lactation.
  • Osteoporosois.
  • Cushing syndrome.
  • Hypersensitivity to any of its components.


Like other corticosteroids, Apidone® should be used cautiously in patients with:

  • History of psychotic illness.
  • Ocular herpes simplex.
  • Increased intra-ocular pressure.
  • Diabetes Mellitus.


Dosage requirements are variable and must be individualized according to severity of the disease and response of the patient:

  • Infants: 1/2 teaspoonfuls twice daily.
  • Children: 1/2 teaspoonfuls three times daily.
  • Adults: 1 teaspoonful three times daily.


  • The dose should be adjusted by the physician.
  • Treatment should not be discontinued abruptly, but the dose should be gradually decreased during withdrawal of the drug (tapering dose).

How Supplied

Bottles of 125 ml syrup.

Keep all medicaments out of reach of children

Product of: AMOUN PHARMACEUTICAL CO. El-Obour City, Cairo, Egypt. ATC Code: H02AB02 , R06AB04.

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