An Overview of Sreek (Secnidazole Tablets)

Sreek, also known as Secnidazole tablets, is an antibiotic medication used to treat certain protozoal infections. This blog post provides an overview of Sreek, including what it is used for, how to take it, potential side effects, and other key information.

What Infections Can Sreek Treat

Sreek exhibits activity against certain anaerobic protozoa, including:

  • Entamoeba histolytica: Which causes amoebiasis (amoebic dysentery)
  • Giardia lamblia: Which causes giardiasis
  • Trichomonas vaginalis: Which causes trichomoniasis

Specifically, Sreek can be used to treat:

  • Intestinal amoebiasis
  • Hepatic (liver) amoebiasis
  • Genitourinary infections caused by Trichomonas vaginalis
  • Giardiasis

How Sreek Works

Sreek contains the active drug secnidazole. Secnidazole is a nitroimidazole antibiotic that works by interfering with the DNA of microorganisms, preventing them from further growth and reproduction.

Compared to similar antibiotics, secnidazole has a longer half-life, allowing it to provide 3 days of antiprotozoal action from a single dose. This helps improve compliance since the full treatment only takes 1-3 days.

Dosage Information

  • Sreek comes as a film-coated 1000 mg tablet that is taken by mouth
  • The dosage is based on the type of infection being treated:

For amoebiasis:

  • Adults: 2 gm single dose (2 tablets), taken before a meal
  • Children: 30 mg/kg single dose, taken before a meal

For giardiasis:

  • Adults: 2 gm single dose
  • Children: 35-50 mg/kg single dose

For trichomoniasis:

  • Adults: 2 gm single dose
  • Both partners should be treated at the same time

Taking Sreek with Food and Alcohol

  • Take Sreek tablets just before a meal
  • Avoid alcohol while taking Sreek and for 3 days after finishing treatment. Alcohol can cause an unpleasant reaction.

Side Effects and Precautions

  • Gastrointestinal upset: Like nausea, metallic taste, abdominal discomfort
  • Allergic reaction: Skin rash, hives
  • Blood disorders in rare cases
  • Neurological effects like pins and needles, numbness, or unsteadiness also rarely occur.

Sreek should not be taken by those with:

  • Known hypersensitivity to secnidazole or similar antibiotics
  • A history of blood disorders

Use caution if taking Sreek with blood thinners like warfarin, as interactions can occur.

Use During Pregnancy and Breastfeeding

  • Sreek should be avoided in the first trimester of pregnancy
  • Sreek passes into breast milk and should be avoided during breastfeeding

How Supplied and Stored

  • Comes in blister packs containing 2 x 1000 mg film-coated Sreek tablets
  • Store in a cool, dry area away from excess heat
  • Shelf life is 5 years

Frequently Asked Questions About Sreek

Here are answers to some common questions about Sreek (Secnidazole) tablets:

1. What infections does Sreek treat?

Sreek treats protozoal infections caused by Entamoeba histolytica, Giardia lamblia, and Trichomonas vaginalis. This includes amoebiasis (amoebic dysentery), giardiasis, trichomoniasis, and related conditions.

2. What are some symptoms of the infections Sreek is used for?

  • Amoebiasis can cause diarrhea, stomach pain, dehydration, fatigue and weight loss from intestinal infection. Invasive disease also occurs.
  • Giardiasis leads to greasy diarrhea, gas, nausea, dehydration, and weight loss.
  • Trichomoniasis causes genital inflammation with burning/itching and an unpleasant discharge in both men and women.

3. Is Sreek approved for use in children?

Yes. Sreek can be used to treat protozoal infections in children. The dosage must be adjusted based on the child’s weight to 30-50 mg per kg of body weight. Child-friendly formulations like oral suspension may also be available.

4. How long does it take for Sreek to cure an infection?

In most cases, the single 2 gram (2 tablet) dose of Sreek provides 3 days of antiprotozoal action, which is enough to clear the infection fully. A few conditions like intestinal amoebiasis require only a single dose, while a short 3-5 day course is used for others.

5. Can Sreek be taken together with other medications?

Sreek has not been shown to interact significantly with most common medications. However, alcohol should be avoided as it can cause reactions. Use with blood thinners like warfarin requires monitoring. Discuss all current medicines with your doctor before starting Sreek.

6. Does Sreek have any serious side effects?

The most common side effects of Sreek are fairly mild, including nausea, strange tastes, etc. Serious allergic reactions are very rare. Use of Sreek has not been linked to organ damage, permanent health conditions or risks that would prevent its use in indicated infections.

7. Can Sreek cure amoebic liver abscesses?

Sreek alone may not be adequate for invasive amoebic liver abscesses. Drainage of the abscess is also required, along with 21+ days of antibiotic treatment. However, Sreek remains beneficial for clearing intestinal Entamoeba infection that allowed spread to the liver.

8. Why can Sreek be taken on an empty stomach but not with alcohol?

Administering Sreek just before meals helps increase absorption from the gut so that adequate drug levels are reached to kill pathogens. Alcohol is not recommended because both share similar chemical structures, raising risk of reactions like nausea and skin flushing due to conflicting metabolism pathways.

9. Is there an over-the-counter version of Sreek available?

No, Sreek (secnidazole) is only available by prescription. Self-treatment with over-the-counter products is not possible. See your healthcare provider if protozoal infection is suspected so proper diagnostic tests and the Sreek prescription treatment regimen can be ordered.

10. How long do the effects of Sreek last after finishing the treatment?

The therapeutic effects of Sreek extend for 72-96 hours after the last dose is taken. This allows full eradication of all susceptible pathogens. Recurrence is unlikely but retesting several weeks later may be undertaken in complicated infections. Symptoms should steadily improve once the protozoa have been eliminated.

In Conclusion

Sreek (Secnidazole) offers high efficacy protozoal treatment with easier dosing and shorter duration of therapy compared to older alternatives. By selectively targeting infectious organisms over human cells, Sreek provides targeted antibiotic action with solid safety and side effect profile. Single dose therapy for intestinal bugs like Giardia facilitates adherence. Follow all instructions to ensure complete clearance of any parasitic infection for which Sreek has been appropriately prescribed.