A Simple Guide to CADMLO-5/10 Amlodipine Besilate Tablets

If you’ve been prescribed CADMLO-5/10 Amlodipine Besilate Tablets, this guide will provide you with the essential information you need to understand the medication, its uses, dosage, and more.

1. Understanding the Composition

CADMLO-5 and CADMLO-10 are two variants of Amlodipine Besilate Tablets, which belong to the therapeutic class of Calcium Channel Blockers. Each tablet contains Amlodipine Besilate, equivalent to a specific dose:

  • CADMLO-5: 5 mg of Amlodipine Besilate
  • CADMLO-10: 10 mg of Amlodipine Besilate

These tablets work by inhibiting calcium ions from entering specific areas of vascular smooth muscle and myocardium, leading to the relaxation of coronary vascular smooth muscle and coronary vasodilation. This helps increase myocardial oxygen delivery, particularly in patients with vasospastic angina.

2. Dosage and Administration

Proper dosage is crucial for effective treatment. Here’s a breakdown of the recommended doses based on different conditions:

For Hypertension

  • Initial dose: 5 mg once daily
  • Maximum dose: 10 mg once daily

Small, fragile, or elderly individuals, as well as patients with hepatic insufficiency, may be started on a lower initial dose of 2.5 mg once daily. This lower dose can also be used when adding amlodipine to other antihypertensive therapy.

For Chronic Stable or Vasospastic Angina

  • Dose: 5-10 mg
  • Lower dose: 2.5 mg in the elderly and in patients with hepatic insufficiency

For Children

In pediatric patients aged 6-17 years, the effective antihypertensive oral dose is 2.5 mg to 5 mg once daily. Doses exceeding 5 mg daily have not been studied in pediatric patients.

3. Indications for Use

Amlodipine Besilate Tablets are prescribed for the following conditions:

  • Hypertension: To manage high blood pressure.
  • Chronic Stable Angina: To treat chest pain caused by a lack of blood flow to the heart.
  • Vasospastic Angina (Prinzmetal’s or Variant Angina): To relieve spasms of the coronary arteries, which can lead to chest pain.

You can use Amlodipine Besilate Tablets as a standalone treatment or in combination with other antihypertensive or antianginal drugs.

4. Contraindications and Possible Side Effects

Before taking CADMLO-5/10 Amlodipine Besilate Tablets, it’s important to be aware of contraindications and potential side effects:

Contraindications: Do not take these tablets if you are hypersensitive to amlodipine or any component of the formulation.

Side Effects: While Amlodipine is generally well-tolerated, some side effects may occur, including headache, edema, fatigue, somnolence, nausea, abdominal pain, flushing, palpitations, and dizziness. Less commonly observed side effects include pruritus, rash, dyspnea, asthenia, muscle cramps, and dyspepsia. Rarely, myocardial infarction and chest pain have been reported.

5. Warnings and Precautions

When using CADMLO-5/10 Amlodipine Besilate Tablets, take note of the following:

  • Increased angina and/or myocardial infarction (MI) may occur with the initiation or dosage adjustment of calcium channel blockers.
  • Use caution in patients with severe aortic stenosis.
  • Be careful if you have severe hepatic impairment.
  • Dosage titration should occur after 7-14 days on a given dose.

6. Additional Information

Pharmacokinetics: Amlodipine’s bioavailability is not significantly altered by the presence of food. It is primarily metabolized in the liver and excreted in the urine. The elimination half-life is approximately 30-50 hours.

Storage: Store the tablets below 30°C and protect them from light.

Shelf Life: The shelf life of these tablets is 36 months.

Remember to follow your healthcare provider’s recommendations for the best results. If you have any concerns or experience adverse effects, consult your doctor or pharmacist for guidance. Your health and well-being are of utmost importance.